Dual cardiac contractile effects of the 2-AMPK deletion in low-flow ischemia and reperfusion
نویسندگان
چکیده
Karla Carvajal, Elham Zarrinpashneh, Ondrej Szarszoi, Frederic Joubert, Yoni Athea, Philippe Mateo, Brigitte Gillet, Sophie Vaulont, Benoit Viollet, Xavier Bigard, Luc Bertrand, Renée Ventura-Clapier, and Jacqueline A. Hoerter INSERM U769, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France; Division of Cardiology, School of Medecine, Université Catholique de Louvain, Brussels, Belgium; RMN Biologique, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France; and Institut Cochin, INSERM U567, Centre National de la Recherche Scientifique UMR-8104, Université Paris 5, Paris, France; and Département des Facteurs Humains, Centre Recherche Service Santé Armée, La Tronche, France
منابع مشابه
Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion.
Because the question "is AMP-activated protein kinase (AMPK) alpha(2)-isoform a friend or a foe in the protection of the myocardium against ischemia-reperfusion injury?" is still in debate, we studied the functional consequence of its deletion on the contractility, the energetics, and the respiration of the isolated perfused heart and characterized the response to low-flow ischemia and reperfus...
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